How it went
Did it last?
- 4 of 29 said the benefit wore off (including the 1 who relapsed).
- 5 of 29 needed to keep doing it to stay well.
Read from what people wrote. A story that ends without a follow-up counts as lasting, so treat these as minimums.
| Outcome described | Accounts | Share |
|---|---|---|
| Full recovery | 1 | 3% |
| Near-full | 3 | 10% |
| Substantial | 10 | 34% |
| Partial | 13 | 45% |
| Relapsed | 1 | 3% |
| No benefit | 1 | 3% |
By how ill people were
| Severity at worst | How it went | n | Recovered |
|---|---|---|---|
| Mild | 2 | 0% | |
| Moderate | 7 | 29% | |
| Severe | 10 | 20% | |
| Very severe | 1 | 0% |
9 accounts don’t say how ill the person was.
How often it comes up
Posts that mention NAD+ boosters (NMN, nicotinamide riboside, NADH, ATP), per 1,000 posts each year. Hover a point for the count.
Show as a table
| Year | Posts mentioning it | All posts | Per 1,000 |
|---|---|---|---|
| 2009 | 0 | 184 | 0.0 |
| 2010 | 1 | 682 | 1.5 |
| 2011 | 2 | 704 | 2.8 |
| 2012 | 7 | 1,491 | 4.7 |
| 2013 | 5 | 1,995 | 2.5 |
| 2014 | 8 | 2,707 | 3.0 |
| 2015 | 1 | 2,566 | 0.4 |
| 2016 | 2 | 2,023 | 1.0 |
| 2017 | 3 | 3,381 | 0.9 |
| 2018 | 88 | 2,523 | 34.9 |
| 2019 | 33 | 1,637 | 20.2 |
| 2020 | 80 | 3,318 | 24.1 |
| 2021 | 31 | 2,469 | 12.6 |
| 2022 | 6 | 1,871 | 3.2 |
| 2023 | 6 | 2,362 | 2.5 |
| 2024 | 4 | 2,176 | 1.8 |
| 2025 | 1 | 1,349 | 0.7 |
| 2026 (so far) | 2 | 899 | 2.2 |
Posts in the forum threads and blog comments we archived, 34,337 in all, counted per year. A mention means the post names the treatment, not that the writer took it. These pages all contain a recovery story, so they show what those communities discussed, not everyone with ME/CFS or long COVID. All trends
All 29 accounts
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Case Report: mitochondrial insufficiency and cholinergic failure in post-vaccination LC
This 80-year-old professor was given Mestinon (pyridostigmine bromide) 90 mg daily for balance problems, which brought minimal benefit over two months, and then a mitochondrial support protocol targeting NAD+ repletion, electron transport chain function and…
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Long Covid/ME/CFS Patient Goes From Moderate To Remission After Just 4 Days Of A Water Fast
A 4-day water fast, not strictly water-only since it included vegetable broth twice daily alongside bromelain and nicotinamide riboside supplements, is credited with a rapid turnaround. The patient was moderate, bordering on severe, beforehand; exact illness…
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Long COVID/ME-CFS Patient Goes from Moderate to Remission After Just 4 Days of a Water Fast
This moderate-bordering-on-severe long-COVID/ME-CFS patient did a 4-day water fast (not fully strict, with broth and some supplements) and reached near-remission afterward. As of the report, the improvement had been maintained for over two months post-fast,…
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List of ME/CFS Recovery and Improvement Stories (page 14 discussion)
ixikd2025 credited a broad, kitchen-sink regimen spanning stimulant, mitochondrial, antihistamine/MCAS, and lifestyle interventions (meditation, running, acupuncture) for significant improvement. With so many concurrent changes, no single component could be…
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ATP working well for me
After COVID worsened his decades-old condition, Keshav began sublingual ATP and reports dramatic improvement within 3 days, and within 24 hours of his first injectable ATP dose felt his "mind was much sharper," mood and energy much better. Follow-up posts…
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CBT for CFS: Luke Shares His Experience and Recovery
Luke combined self-directed CBT (working through his own negative thought patterns rather than with a therapist) with a methylation protocol developed by Rich Von Konynenburg (B vitamins plus folic acid), guidance from two books -- Kristina Downing-Orr's…
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ME/CFS patient goes into remission after taking GDF11
Ill for fifteen years and bedbound as recently as 2016, this patient self-injected the GDF11 protein subcutaneously every other day alongside an NMN supplement. After about two months he reported feeling one hundred per cent cured, with dramatic resolution…
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Mitochondrial and Energy Metabolism Dysfunction in ME/CFS - Myhill, Booth and McLaren-Howard Papers
MrTwoToedSloth, mostly housebound and limited to about one activity a week before a week-long flare-up, assembled a broad mitochondrial-support stack (CoQ10, acetyl-L-carnitine, nicotinamide riboside, creatine, D-ribose and more) and noticed improvement at…
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Hyperalgesia and pain resolved with INOSINE
A combination of inosine and caffeine with calcium glutarate, several minerals/B6 and later ribose produced "complete reversion" of longstanding neuropathic pain and pain-free mornings, plus better tolerance of B-vitamin injections. She is explicit it is not…
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Instant relief with inosine plus caffeine
pattismith reports that inosine combined with caffeine relieves her muscle weakness/pain and brain fog within about an hour of taking it, and as of a follow-up three weeks later says it is "still working for me." This reads as reliable short-acting symptom…
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From brain fog to clarity in 30 minutes
A five-supplement mitochondrial stack -- ubiquinol, nicotinamide riboside, fursultiamine, dichloroacetate and PQQ -- reportedly clears his brain fog within about 30 minutes of dosing and gets him to "close to normal" function from a mild/SEID baseline. He is…
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7 Day NAD+ Infusions (Severe ME/CFS Recovery, Neurological / Mitochondrial / Genetic Repair) + POLL
Combined a weekly IV infusion of NAD+ with daily oral NAD+ lozenges at 25mg for three-plus weeks, and reports being able to ski for five hours the previous week, "first time in 3 years." Frames it as self-experimentation rather than a confirmed treatment --…
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Treating patients suffering from (ME/CFS) with sodium dicholoracetate
Dichloroacetate (sodium DCA) was taken at 333 mg twice daily, alongside fursultiamine, nicotinamide riboside and ubiquinol, for about two weeks at the time of posting. The account does not state prior illness duration or severity. After roughly two weeks the…
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M.E., My Mold, and I: A Story of ME/CFS and Toxic Mold
Over nearly seven years of ME/CFS beginning in late summer 2010, she tried pacing with a heart-rate monitor and many supplements, including herbal antivirals, for about a year, then added neurotransmitter support (dopamine, GABA), an ATP Fuel supplement,…
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Possible CFS success story. Got much better after 4-5 years. Here's what has helped.
Never formally diagnosed but self-describing as a mild case, this poster went from an estimated 20% to 70-90% of normal functioning over 4-5 years on a large stack (St. John's Wort, 15g/day D-ribose, melatonin/Seriphos, acetyl-L-carnitine, fish oil) plus a…
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Combination of Supplements Allows Me to Work and Exercise - But causes extreme Gastritis
Built a roughly 60-item daily supplement stack (B12, NADH, high-dose antioxidants/glutathione, SAM-e, CoQ10, glandulars, ribose, phosphatidylserine and more) over three-plus years of trial and error for CFS, fibromyalgia and Hashimoto's. Says the combination…
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METHYLATION, B VITAMINS(ETC), SKIN RASH ITCH RESOLVED
A worsening skin rash and itch on his prior NADH/FADH2/methylcobalamin/Peak ATP protocol led him to stop it and switch to dry skin brushing, coffee retention enemas, TMG and potassium as a detox approach. The itch resolved, but he expected to need ongoing…
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NAD -- surprising
Also tried 25mg sublingual NAD and got a lower heart rate and an energy boost, but felt "too wired up" on it and had to take a break to reassess -- a substantial physiological effect that was not tolerable enough to continue using as-is.
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NAD -- surprising
Tried sublingual NAD (25mg) and saw resting heart rate drop from the 90s into the 80s (about 10 bpm) and active heart rate drop 10-15 bpm, with enough extra exercise tolerance to run stairs without crossing into anaerobic threshold. The effect "tended to…
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What treatments HAVE ACTUALLY helped?
Took a mitochondrial-support stack of CoQ10, B3, magnesium and zinc after being, in her words, "totally bed ridden with super low ATP." Reports being "much better than I was," a substantial gain, but says she is "still mostly house bound" and was actively…
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How to take d-ribose for energy - it really works!
Takes d-ribose one scoop three times a day alongside L-carnitine and other supplements. Titled her update "P.O.T.S. now SO MUCH BETTER!" and says she "can walk much better now" compared to previously being unable to walk more than a few steps, describing the…
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How to take d-ribose for energy - it really works!
Took 2 tablespoons of d-ribose three times a day and says it helped enough that she "could stand in the kitchen long enough to make dinner," a real but modest functional gain. She herself calls the results "not that impressive" relative to the cost and…
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How to take d-ribose for energy - it really works!
Has taken d-ribose for about 3 years; the initial energy boost wore off over that time, so she switched to a smaller, more frequent dosing schedule (1/2 tsp six times daily, working toward 15g/day). Ten days into the new regimen she reports overall energy…
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My complete protocol - recovering well from bad 7 years+ CFS
Ran a broad two-year self-built protocol - high-dose B vitamins, vitamin D3, D-ribose, CoQ10, acetyl-L-carnitine, a sublingual/nasal B12-folate methylation stack, amino acids, Buteyko breathing, infrared sauna and transdermal magnesium - layered onto months…
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Battle of the NAD boosters poll (NMN, NAD+, NR)
Trans-resveratrol, combined with NMN, TMG and quercetin, gave this ME/CFS patient an "enormous energy boost" by their own description. Doses and length of use are not specified. Illness duration before starting is also not stated. Resveratrol was one of four…
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Battle of the NAD boosters poll (NMN, NAD+, NR)
NMN was tried at high dosages for several months by this ME/CFS patient, who reports it "did nothing" for his symptoms. Illness duration before the trial is not stated. He had tested numerous other NAD+ precursors and delivery routes, and found NADH…
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Why NMN and NR is not curing our CFS?
NMN, at an unspecified dose, was reported as helping broadly across symptoms after about a week of use. Illness duration before starting is not stated. The person specifically noted losing the morning "hyper-nervous, hyper-sensitivity" feeling and described…
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Mending the Mitochondria: Lipid Replacement Therapy for Chronic Fatigue Syndrome
NT Factor (a single dose), followed by ATP Fuel at a reduced dose because it felt too stimulating, plus regular glycerophosphocholine and phosphatidylserine (branded Brain Vitale) for ongoing mental clarity. The author, a clinician diagnosed with chronic…
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Long COVID Recovery - 3 Personal Stories of Healing (Heydieh)
Heydieh's protocol combined three EBOO/F (extracorporeal blood oxygenation, ozonation and filtration) sessions with about five high-dose "10 Pass" ozone sessions, hyperbaric oxygen therapy, and IV infusions of high-potency vitamin C, NAD, methylene blue and…