Miruvor
Long COVID Very severe → partialIll for 3 yearsNeeds ongoing treatment

Impact of extended-course Paxlovid in established Long COVID (Case 11)

Case 11pmc.ncbi.nlm.nih.govPublished 2023

Condition
Long COVID
At worst
Very severe (bedbound, unable to do basic care)
Ill for
3 years
Published
2023

Summary

Case 11, a 33-year-old woman roughly three years into severe Long COVID/ME since March 2020, initially bedridden and dependent on caregivers and later "mostly housebound," had a 5-day Paxlovid course in May 2022 that brought significant improvement, ending her bedridden state and easing other symptoms. A further 5-day attempt in June 2022 and a 15-day attempt in February 2023, the latter on top of escitalopram, propranolol and low-dose naltrexone, both had to be stopped within 5 hours of the first dose due to severe stomach pain, so she never completed an extended course. The gains from the original 5-day course persisted, but she continues to experience the same Long COVID symptoms and significant functional limitations, with no extended treatment tolerated since.

Read it in their words

pmc.ncbi.nlm.nih.gov

Read the original ↗ Archived copy

What they credit

Low-dose naltrexonePOTS medicationPaxlovidBeta-blockersLow-dose naltrexonePaxlovid / nirmatrelvirSSRIs and antidepressants

Symptoms mentioned

Pain & fibromyalgia

Similar stories

  • How I got in remission/cured my ME/CFS

    Full recovery ME/CFS SevereIll 3 years forums.phoenixrising.me Aug 2025

    Ali_Mardiyev, disabled for 1.5 years with POTS/dysautonomia/severe fatigue/PEM, layered a stellate ganglion block with beta-blocker, a testosterone course, several psychiatric medications, intermittent fasting and a slow graded-exercise ramp starting April…

  • Michelle

    Substantial Long COVID Very severeIll 6 months longcovidcured.com Jan 2023

    Michelle saw more than ten specialists and tried extensive medical treatment: beta blockers, the migraine drug Ubrelvy, meclizine for dizziness, two rounds of prednisone, B12 shots for neuropathy, and Paxlovid taken months after her initial infection, plus…

  • Impact of extended-course Paxlovid in established Long COVID (Case 7)

    Relapsed Long COVID SevereIll 11 monthsEffect faded pmc.ncbi.nlm.nih.gov 2023

    Case 7, a 29-year-old man about 10 months into Long COVID/ME since July 2022 with extreme fatigue, PEM, tachycardia, POTS, persistent headache, brain fog, chest pain and shortness of breath, took a 15-day extended Paxlovid course in May 2023 while also on…

  • Robyn Dale

    Near-full Long COVID Very severeIll 5 months positivelycovid.org Jun 2022

    Robyn's treatment combined short courses of propranolol, zopiclone and diazepam early on with medium-term amitriptyline for insomnia, mood and muscle spasms, alongside daily walking, yoga, meditation and graded activity. She crashed severely in December 2021…