How it went
Did it last?
- 4 of 5 said the benefit wore off (including the 2 who relapsed).
- No one said they needed to keep it up to stay well.
Read from what people wrote. A story that ends without a follow-up counts as lasting, so treat these as minimums.
| Outcome described | Accounts | Share |
|---|---|---|
| Full recovery | 0 | 0% |
| Near-full | 0 | 0% |
| Substantial | 2 | 40% |
| Partial | 1 | 20% |
| Relapsed | 2 | 40% |
| No benefit | 0 | 0% |
Only 5 accounts. Treat these percentages as anecdotes, not rates.
By how ill people were
| Severity at worst | How it went | n | Recovered |
|---|---|---|---|
| Moderate | 1 | 0% | |
| Very severe | 1 | 0% |
3 accounts don’t say how ill the person was.
Who published these accounts
Right-hand number: share describing a full or near-full recovery. Pages that sell something, and advocacy sites, tend to publish only the successes.
How often it comes up
Posts that mention Modafinil / armodafinil, per 1,000 posts each year. Hover a point for the count.
Show as a table
| Year | Posts mentioning it | All posts | Per 1,000 |
|---|---|---|---|
| 2009 | 0 | 184 | 0.0 |
| 2010 | 2 | 682 | 2.9 |
| 2011 | 2 | 704 | 2.8 |
| 2012 | 2 | 1,491 | 1.3 |
| 2013 | 0 | 1,708 | 0.0 |
| 2014 | 0 | 2,352 | 0.0 |
| 2015 | 7 | 2,158 | 3.2 |
| 2016 | 8 | 1,431 | 5.6 |
| 2017 | 4 | 3,110 | 1.3 |
| 2018 | 0 | 2,201 | 0.0 |
| 2019 | 0 | 1,075 | 0.0 |
| 2020 | 8 | 2,581 | 3.1 |
| 2021 | 18 | 1,867 | 9.6 |
| 2022 | 9 | 1,166 | 7.7 |
| 2023 | 0 | 1,000 | 0.0 |
| 2024 | 1 | 1,237 | 0.8 |
| 2025 | 1 | 1,019 | 1.0 |
| 2026 (so far) | 2 | 840 | 2.4 |
Posts in the forum threads we archived, 26,806 in all, counted per year. A mention means the post names the treatment, not that the writer took it. These threads all contain a recovery story, so they show what those communities discussed, not everyone with ME/CFS or long COVID. All trends
All 5 accounts
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I finally fixed post-COVID fatigue
D.Rabbie says a combination of the vasoactive drug heptaminol with cinnarizine, and later with modafinil, gave him "better energy and mental clarity" that he felt exceeded his pre-COVID baseline, after two to three months of unresolving post-COVID fatigue…
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The Awakening - Bedbound to Housebound (1 Day a week)
Uses a precisely timed stack -- pregabalin and agmatine after a first sleep block, then modafinil and piracetam on waking -- to engineer roughly one functional day per week after five years bedbound. Says it lets him "talk to friends, use my laptop, get jobs…
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Modafinil for Chronic Fatigue Syndrome Reviews
Modafinil at 200mg, split between morning and afternoon doses, was tried by a chronic fatigue patient who rated the result 1 out of 10. Rather than helping, it worsened their fatigue, leaving them in what they called zombie mode. They report the drug was…
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Modafinil for Chronic Fatigue Syndrome Reviews
Modafinil, taken as needed at around 100mg by someone who rated the drug 10 out of 10, produced what they called a life-changing result. They report returning to work as a cab driver and having clearer thinking on the drug. No specific illness severity grade…
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Modafinil for Chronic Fatigue Syndrome Reviews
Modafinil, titrated from 200mg up to 300mg and then 400mg daily over time, initially produced significant improvement in fatigue and brain fog, rated 8 out of 10 overall. The reviewer reported that the drug's efficacy diminished over three years of use,…