Mestinon, Chronic Fatigue, Vagus Nerve Stimulation and Exercise
- Condition
- ME/CFS
- At worst
- Very severe (bedbound, unable to do basic care)
- Ill for
- 28 years
- Published
- Jun 2016
Summary
After 28 years of never being able to exercise despite seeing top ME/CFS specialists worldwide, and a recent low point involving surgeries, ER visits and a drug reaction, this patient started 180mg/day Mestinon and within weeks felt an urge to run for the first time in decades. She went on to run 3+ miles several times a week, cross-country ski and gym-train with no PEM afterward, reaching roughly 80% function; the gains were reported as sustained, with the patient still active in the comments years later.
What they credit
Credits POTS medication, Vagus nerve stimulation, Mestinon / pyridostigmine, PDE5 inhibitors (sildenafil, tadalafil), Vagus nerve stimulation.
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